Migraine Formula Caplets contain acetaminophen 250 mg, aspirin 250 mg (NSAID), and caffeine 65 mg. Compared to the active ingredients in Excedrin Migraine.

Active Ingredients (In each caplet): Acetaminophen (250 mg), Aspirin (250 mg), (NSAID*), Caffeine (65 mg) *nonsteroidal anti-inflammatory drug.

Inactive Ingredients: Carnauba Wax, Crospovidone, FD&C Blue #1 Aluminum Lake, Hypromellose, Microcrystalline Cellulose, Povidone, Pregelatinized Starch, Propylene Glycol, Saccharin Sodium, Stearic Acid, Titanium Dioxide

• Do not use more than directed.
• Adults: Take 2 caplets with a glass of water; if symptoms persist or worsen, ask your doctor. Do not take more than 2 caplets in 24 hours, unless directed by a doctor.
• Under 18 years of age ask a doctor.

Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. 

When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. 

Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include skin reddening, blisters, or a rash. If a skin reaction occurs, stop use and seek medical help right away. 

Allergy alert: Aspirin may cause a severe allergic reaction which may include hives, facial swelling, asthma (wheezing), and shock. 

Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take:

• More than 2 caplets in 24 hours, which is the maximum daily amount
• With other drugs containing acetaminophen
• 3 or more alcoholic drinks every day while using this product

Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you:  

• Are age 60 or older
• Have had stomach ulcers or bleeding problems
• Take a blood thinning (anticoagulant) or steroid drug
• Take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
• Have 3 or more alcoholic drinks every day while using this product
• Take more or for a longer time than directed

Medication overuse headache warning: Headaches may worsen if this product is used for 10 or more days per month. 

Caffeine warning: The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and occasionally, rapid heart beat. 

Do not use: 

• If you have ever had an allergic reaction to acetaminophen, aspirin, or any other pain reliever/fever reducer
• With any other drug containing acetaminophen (prescription or nonprescription)

If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. 

Ask a doctor before use if: 

• You have never had migraines diagnosed by a health professional
• You have a headache that is different from your usual migraines
• You have the worst headache of your life
• You have fever and stiff neck
• You have headaches beginning after or caused by head injury, exertion, coughing, or bending
• You experienced your first headache after the age of 50
• You have daily headaches
• You have a migraine so severe as to require bed rest
• You have liver disease
• Stomach bleeding warning applies to you
• You have a history of stomach problems, such as heartburn
• You have high blood pressure, heart disease, liver cirrhosis, or kidney disease
• You are taking a diuretic
• You have asthma
• You have problems or serious side effects from taking pain relievers or fever reducers
• You have vomiting with your migraine headache

Ask a doctor or pharmacist before use if you are: 

• Taking a prescription drug for diabetes, gout, arthritis, under a doctor’s care for any serious condition, taking any other drug, taking any other product that contains aspirin, acetaminophen, or any other pain reliever/fever reducer

Stop use and ask a doctor if an allergic reaction occurs. 

Seek medical help right away if you experience any of the following signs of stomach bleeding: 

• Feel faint
• Vomit blood
• Have bloody or black stools
• Have stomach pain that does not get better
• Your migraine is not relieved or worsens after first dose
• New or unexpected symptoms occur
• Ringing in the ears or loss of hearing occurs

If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery. 

Keep out of reach of children. 

In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222) Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.